流行性乙型脑炎的教育.pptxVIP

流行性乙型脑炎的教育第1页/共49页 Epidemic Encephalitis B 第2页/共49页 Case reportHistory taking：A boy,4 years old，born in the countryside.Fever last for 4 days，convulsion and confusion last about 6 hours.Physical examination：T 40.5℃，R 30bpm，P 120bpm，BP100/60mmHg. Unconsciousness, conjunctival edema, lungs can be heard wheezes. Muscle hypertonia, knee hyperreflexia, Babinski sign(+)Other history?Accessory examination?第3页/共49页 AbstractJapanese encephalitis(JE), an acute infectious disease caused by the mosquito-borne Japanese encephalitis virus(JEV) and featured as inflammation in brain parenchyma.Fever, confusion, coma, convulsion,pathological reflex and meningeal irritation . Respiratory failure in severe cases,high mortality,and10% result in permanent neuropsychiatric sequelea.第4页/共49页 EtiologyA single stranded RNA, 40-50nm,11 kilobases genomes.RNA genome is packaged in the capsid protein forming the core of the virus.The genomes also encodes several nonstructural proteins (NS1,NS2a,NS3,NS4a,NS4b,and NS5)JEV can be killed by disinfectant,100 ℃ 2 minutes or 56 ℃ 30 minutes第5页/共49页 EtiologyAntigenic stability, infection can produce complement-binding antibodies, neutralizing antibodies and hemagglutination inhibition antibodies, contribute to clinical diagnosis and epidemiological investigation第6页/共49页 EpidemiologySources of infection: JE is a zoonosis, mosquitoes become infected by feeding domestic pigs and wild birds infected with the JEV. JEV is amplified in the blood systems of the domestic pigs and wild birds. Pigs are the improtant amplified and reservoirs.Other reservior includes cow, sheep, horse,duck,goose and chicken.第7页/共49页 EpidemiologyRoute of transmission: the bite of an infected mosquito, primarily Culex species. Humans are a dead-end host in the JEV tramsmission cycle. JEV is not transmitted from person-to-person. Only domestic pigs and wild birds are carriers of the JEV.第8页/共49页 Epidemiology.Susceptible population: Generally susceptible, especially residents of