纳米反应器研究进展.pptxVIP

纳米反应器研究进展第1页/共42页 Contents? Concept of NanoReactor? Recent Developments of Nanoreactors Molecular Nanoreactor Macromolecular Nanoreactor Bio-macromolecular Nanoreactor? Outlook第2页/共42页 NanoReactorreactantsproductsInspired by NatureNanoReactorCompartmentalization /Accumulation / Confinement Stabilized specific transition states products(Cascade Reaction in Time Space)(Tuned Activity, Selectivity Stability)Well-defined Reaction Environments Chemical Conversions in NatureEnzyme ------ Cell nm μmCoupling of Reactions in Time Space第3页/共42页 DimensionMolecular NanoreactorSupramolecular NanoreactorMacromolecular NanoreactorBiomacromolecular NaonoreactorBuilt-up viaCovalent bondH-bondComplexationElectrostaticsVan der WaalsNanoReactorApplications:Target chemical synthesis, nanoparticle synthesis,catalysis, sensor, detector…Molecular NanoreactorSupramolecular Macromolecular NanoreactorBiomacromolecular Nanoreactor第4页/共42页 Molecular NanoreactorSpecific Binding Interaction (directional, selective) Stabilized Transition State Lowered Ea Renstein, D. G. Chem. Rev. 1987, 87, 1047. Kirby, A. J. Angew. Chem., Int. Ed. Engl. 1996, 35, 707.Selectively Recognize Bind a Desired Substrate.Examples: crown ether, calixrene, cyclodextrin, etc. (Covalent-bonded or self-assembled)Enzyme mimicEnzymeMimicP450Binding CavityBreslow, R.; Huang, Y.; Zhang, X.; Yang, J. Proc. Natl. Acad.Sci. U.S.A. 1997, 94, 11156.第5页/共42页 1234Breslow, R.; Huang, Y.; Zhang, X.; Yang, J. Proc. Natl. Acad.Sci. U.S.A. 1997, 94, 11156.Covalent Molecular Nanoreactor----Cyclodextrin Fixation EffectEnzyme mimic234Androstane-3,17-diolBreslow, R.; Zhang, X.; Huang, Y. J. Am. Chem. Soc. 1997, 119, 4535.No reactionMixture56第6页/共42页 Noncovalent Molecular NanoreactorsHof, F.; Craig, S. L.; Nuckolls, C.; Rebek, J., Jr. Angew. Chem.,Int. Ed. 2002, 41, 1488.Covalent Non-covalent (reversible)Y . Aoyama, Y. Tanaka, H. Toi, H. Ogoshi,