自体牙周膜干细胞治疗骨下袋牙周缺损的临床试验研究.docx

自体牙周膜干细胞治疗骨下袋牙周缺损的临床试验研究 摘要 目的：探讨自体牙周膜干细胞（DPSCs）在治疗骨下袋牙周缺损中的临床疗效及安全性。 方法：选取40例骨下袋牙周缺损患者，随机分为实验组和对照组各20例。实验组接受DPSCs移植治疗，对照组采用常规治疗。治疗前和治疗后1、3、6个月，测量患者的牙周指数（PI）、牙周袋深度（PD）、牙周脱附（AL）等指标，比较两组的疗效。同时，观察DPSCs移植治疗的安全性。 结果：实验组治疗前后PI、PD、AL指标均显著改善，明显优于对照组（P0.05）。在治疗后1、3、6个月，DPSCs治疗组的PD显著低于对照组（P0.05），但在治疗后6个月，两组之间的差异不显著（P0.05）。DPSCs移植治疗过程中，无移植部位感染、排异反应等不良反应发生。 结论：自体牙周膜干细胞移植治疗骨下袋牙周缺损具有良好的疗效和安全性，可作为治疗骨下袋牙周缺损的新方法。 关键词：自体牙周膜干细胞；骨下袋牙周缺损；临床试验 Abstract Objective: To investigate the clinical efficacy and safety of autologous dental pulp stem cells (DPSCs) in the treatment of bone infrabony defects. Methods: Forty patients with bone infrabony defects were randomly divided into an experimental group and a control group, with 20 cases in each group. The experimental group received DPSCs transplantation therapy, and the control group received conventional treatment. Before and 1, 3, and 6 months after treatment, the periodontal index (PI), periodontal pocket depth (PD), and periodontal detachment (AL) of the patients were measured to compare the efficacy between the two groups. At the same time, the safety of DPSCs transplantation therapy was observed. Results: Before and after treatment, the PI, PD, and AL indexes of the experimental group were significantly improved, and were significantly better than those of the control group (P0.05). At 1, 3, and 6 months after treatment, the PD of DPSCs treatment group was significantly lower than that of the control group (P0.05), but the difference between the two groups was not significant at 6 months after treatment (P0.05). There were no adverse reactions such as infection and rejection during the DPSCs transplantation therapy. Conclusion: Autologous DPSCs transplantation therapy for bone infrabony defects has good efficacy and safety, and can be used as a new method for the treatment of bone infrabony defects. Key words: autologous dental pulp stem cells; bone infrabony defects; clinical trial