蒙古族任娠糖尿病患者肠道菌群的结构特征及其与代谢、炎.docx

蒙古族任娠糖尿病患者肠道菌群的结构特征及其与代谢、炎 摘要： 蒙古族人群中任娠期糖尿病（GDM）的发生率较高，与肠道菌群失衡有关。本文采用16S rRNA高通量测序技术分析了蒙古族人群中GDM患者和非GDM组的肠道菌群结构特征，并探究了其与代谢和炎症指标的关系。结果显示，GDM患者的肠道菌群丰富度、Shannon指数、Chao1指数以及某些优势菌种数量与非GDM组存在差异。其代谢物谱分析表明，GDM组与非GDM组之间存在着显著差异，其中丙酮酸、异戊二烯酸和脂肪酸的含量增多，而牛磺酸和胆固醇的含量减少。同时，我们发现GDM组的白细胞计数、C反应蛋白以及IL-6的水平明显升高，而碳水化合物、蛋白质以及脂肪的代谢都受到了不同程度的影响。这些发现说明，肠道菌群失衡可能导致GDM发生的危险性增加，并且与代谢和炎症异常密切相关，有望成为预测和干预GDM的潜在靶点。 关键词：蒙古族；任娠期糖尿病；肠道菌群；代谢物谱；炎症 Abstract: The incidence of gestational diabetes mellitus (GDM) is high in Mongolian population, which is related to the imbalance of intestinal flora. In this study, the structure characteristics of intestinal flora in GDM patients and non-GDM group of Mongolian population were analyzed by 16S rRNA high-throughput sequencing technology, and the relationship with metabolic and inflammatory indicators was explored. The results showed that there were differences in the richness, Shannon index, Chao1 index and the number of some dominant bacterial species between GDM patients and non-GDM group. Metabolomic analysis showed that there were significant differences between GDM group and non-GDM group, among which the content of acetone, isovalerate and fatty acids increased, while the content of taurine and cholesterol decreased. At the same time, we found that the white blood cell count, C-reactive protein and IL-6 levels in GDM group were significantly increased, and the metabolism of carbohydrates, proteins and fats were affected to varying degrees. These findings suggest that the imbalance of intestinal flora may increase the risk of GDM, and is closely related to metabolic and inflammatory abnormalities, which is expected to become a potential target for predicting and intervening GDM. Key words: Mongolian ethnic group; gestational diabetes; intestinal flora; metabolomic; inflammation