IDO1-IN-21-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE IDO1-IN-21 Cat. No.: HY-149227 CAS No.: 2892432-98-1 分⼦式: C₂₁H₁₉F₂N₃O₆S 分⼦量: 479.45 作⽤靶点: Indoleamine 2,3-Dioxygenase (IDO) 作⽤通路: Metabolic Enzyme/Protease 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 IDO1-IN-21 (化合物 10m) 是⼀种 IDO1 抑制剂 (IC50 = 0.64 μM)。IDO1-IN-21 能有效抑制⼩⿏体内肿瘤的⽣ 长。 IC50 Target IDO1 0.64 μM (IC50) 体外研究 IDO1-IN-21 (0-50 μM; 48 h) inhibits the viability of SW480 cells with an IC50 value of 28.64 μM [1]. IDO1-IN-21 (0-10 μM; 48 h) inhibits the IDO1 of HeLa cells with an IC50 value of 1.04 μM [1]. Cell Viability Assay [1] Cell Line: SW480 cells Concentration: 0-50 μM Incubation Time: 48 h Result: Surpressed viability of SW480 cells (IC50 = 28.64 μM). 体内研究 IDO1-IN-21 (50, 100 mg/kg; i.p.; every three day for 21 consecutive days) inhibits growth of tumor in CT26 tumor-bearing mice [1]. Animal Model: CT26 tumor-bearing mice [1]. 1/2 Master of Bioactive Molecules — 您⾝边的抑制剂⼤师