从指南到实践社区高危患者血脂规范管理.pptVIP

* 综合JAPAN-ACS研究和SATURN研究我们看到，斑块的逆转并不一定带来终点事件的降低，而斑块体积只是评估动脉粥样硬化研究的替代终点，可以给我们研究带来一些有价值的信息，但不能直接推断到硬终点 * * Large atheroma may not produce flow limiting stenosis. This image shows formation of a substantial atheroma in the arterial intima (yellow zone) with preservation of the lumenal flow channel. An outward bowing of the entire artery accommodates this growth of plaque to preserve the lumen until the later stages of the disease. This outward remodeling, also known as ‘compensatory enlargement,’ accommodates the growing atheroma. * * * Several investigators have examined the question of which t