代谢综合症预防心脏病的前景.pptxVIP

代谢综合症预防心脏病的前景第1页/共32页 Focuses of Current Debates in Metabolic Syndrome第2页/共32页 Definitions??????Etiology and pathophysiology?????? Clinical importance??????? Importance forCVD prevention???????第3页/共32页 Clinical Perspectives for MS● Who are the MS patients ?? (Diagnostic issue)● Who need the clinical treatment among the MS patients and ?? ● How to treat the MS patients ?? (Treatment issue)● The effectiveness of treatment strategies??( Treatment issue)第4页/共32页 The Proportion of MS by Different Criteria for Central ObesityMale Female第5页/共32页 Treatment Decision in MS HypertensionHigh BPHigh TGDiabetesIFGCentral ObesityLow HDL-CWho needs treatment as MS patients? What are the specific targets of treatment for MS patients?第6页/共32页 Preventive Perspectives for MS ● If the major components of MS have common pathophysiological pathway ???● If MS has unique value in prediction of CVD ???● How to prevent MS ?? 第7页/共32页 If the components in MS have common pathophysiological pathway ??? 第8页/共32页 Human obesity …… is due to an excess production of free fatty acids from these lipolytically active depots. This, in turn, might cause hyperinsulinemia via reduced hepatic insulin uptake, followed by peripheral hyper- insulinemia, insulin resistance and, perhaps, diabetes mellitus and hypertension. Bjorntorp P J Clin Hypertension 1986 2:163第9页/共32页 …….These data strongly support the view that insulin play an important role in regulation of HDL metabolism. Golay A J Lipid Res 1987 28:10-18第10页/共32页 Atherosclerotic CVDIGT Type 2 DMdyslipidemia FFA ? TG? HDL-C? BP? Insulin resistance Banting Lecture: Reaven GM 1988Diabetes 37:1595第11页/共32页 Hyperinsulinaemia %The Prevalence of Hyperinsulinaemia by Increasing Numbers of Components in Metabolic Syndrome (CMCS Study, 2002)第12页/共32页 %Percentages of Only One Component of Metabolic Synd