0HMGA2与Wnt、β-catenin信号通路在散在结直肠癌管状腺瘤癌变中的调控作用.pdfVIP

ONCOLOGY LETTERS 22: 849, 2021 Regulatory effect between HMGA2 and the Wnt/β‑catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma DAN LI, YANAN CAO, JUAN WANG, HAIYAN YANG, WEINA LIU, JINFENG CUI and WENXIN WU Department of Pathology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China Received May 14, 2021; Accepted August 31, 2021 DOI: 10.3892/ol.2021.13110 Abstract. Due to the high incidence of colorectal cancer HMGA2 knockdown in the human colorectal cancer cell line, worldwide, the underlying molecular mechanisms have been HCT 116 decreased β‑catenin expression and its downstream extensively investigated. The Wnt/β‑catenin signaling pathway targets, CDK4 and cyclin D1. Furthermore, silencing of Wnt or plays a key role in the carcinogenesis of colorectal adenoma. β‑catenin decreased HMGA2 expression. Taken together, the In addition, the high mobility group AT‑hook 2 (HMGA2) results of the present study suggest the coordinated regulation protein, which is involved in several biological processes, of HMGA2 and the Wnt/β‑catenin signaling pathway in the such as proliferation, differentiation, transformation and carcinogenesis of sporadic colorectal tubular adenoma. metastasis, is expressed at significantly high levels in colorectal cancer tissues compared with adjacent normal Introduction tissues. Currently, the role of HMGA2 in the carcinogenesis of sporadic colorectal tubular adenoma remains unclear. Colorectal adenoma is a rel