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Journal of Ethnopharmacology 282 (2022) 114617 Contents lists available at ScienceDirect Journal of Ethnopharmacology journal homepage: /locate/jethpharm Efficacy and safety of berberine in preventing recurrence of colorectal adenomas: A systematic review and meta-analysis a, 1 c, 1 a, 1 a,b a a ShuangShuang Fang , Song Guo , SiJing Du , Zeng Cao , Yang Yang , XiaoLan Su , Wei Wei a, * a Department of Gastroenterology, Beijing Key Laboratory of Functional Gastrointestinal Disorders Diagnosis and Treatment of Traditional Chinese Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, 100102, Beijing, China b Beijing University of Chinese Medicine, Beijing, 100029, Beijing, China c Department of Gastroenterology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong, 250013, Shandong, China A R T I C L E I N F O A B S T R A C T Keywords: Ethnopharmacological relevance: Berberine(BBR) is a kind of isoquinoline alkaloids extracted from the rhizomes of Colorectal adenomas Coptis chinensis Franch., which was the main active ingredient. Accumulating evidence has shown that it has Berberine potential pharmacological effects in preventing the recurrence of colorectal adenomas. Chemoprevention Aim of t