DL-酒石酸水溶液的溶解度及结晶介稳区研究.pdf

Cryst. Res. Technol. 47, No. 11, 1153–1163 (2012) / DOI 10.1002/crat.201200166 Solubility and metastable zone width of DL-tartaric acid in aqueous solution Xiang-Yang Zhang, Xiaofang Wang, Lin Hao, Xiaowu Yang, Leping Dang*, and Hongyuan Wei School of Chemical Engineering and Technology, Tianjin University, 300072 Tianjin, China Received 11 April 2012, revised 21 August 2012, accepted 22 August 2012 Published online 21 September 2012 Key words solubility, metastable zone width, DL-tartaric acid, dissolution enthalpy, nucleation kinetics, dissolution entropy. Solubility and metastable zone width (MSZW) of DL-tartaric acid (DL-TA) in aqueous solution have been determined. Solubility of DL-TA was measured in the temperature range from 0 to 50 ◦C at atmospheric pressure by means of the conventional polythermal method using Turbidity Monitoring Technique, which was verified by a gravimetric method. The dissolution enthalpy and entropy of DL-TA were then calculated from the solubility data using van’t Hoff equation. Two approaches was used to estimate the nucleation kinetics from the measured metastable zone width data, the self-consistent approach and the approach based on 3D nucleation. In addition, the metastable zone width slightly decreases with increasing agitation rate and was independent of working volume. C 2012 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim 1 Introduction Crystallization has been arguably the most important separation and purification process operation in the phar- maceutical