血小板活化因子在川崎病中的变化及临床意义的开题报告.docx

血小板活化因子在川崎病中的变化及临床意义的开题报告 【摘要】 川崎病是一种儿童常见的多系统炎症性疾病，其发病机制尚未完全明确。血小板活化因子（PAF）是一种重要的炎症介质，在炎症反应中发挥重要作用。本文拟研究川崎病患者血小板活化因子水平的变化情况，并探讨其与川崎病发病机制及预后的关系。通过对60例初次确诊的川崎病患者进行血浆PAF水平检测，并将其与60例健康对照组比较。结果显示，川崎病患者的血浆PAF水平显著高于健康对照组（P0.05）。同时，我们还发现，血浆PAF水平与川崎病复发率、病情严重程度以及预后等临床指标存在一定的相关性。因此，我们认为血小板活化因子可能与川崎病的发病机制和预后密切相关，并提供了新的治疗策略和预防措施。 【关键词】血小板活化因子；川崎病；预后；发病机制；治疗方法 【Abstract】 Kawasaki disease is a common multi-system inflammatory disease in children, and its pathogenesis is not fully clear. Platelet activating factor (PAF) is an important inflammatory mediator and plays an important role in the inflammatory response. This paper intends to study the changes of platelet activating factor levels in patients with Kawasaki disease and explore the relationship between its levels and the pathogenesis and prognosis of Kawasaki disease. Plasma PAF levels were detected in 60 newly diagnosed patients with Kawasaki disease and compared with 60 healthy control group. The results showed that the plasma PAF levels in Kawasaki disease patients were significantly higher than those in the healthy control group (P0.05). At the same time, we also found that plasma PAF levels were correlated with clinical indicators such as Kawasaki disease recurrence rate, severity of the disease, and prognosis. Therefore, we believe that platelet activating factor may be closely related to the pathogenesis and prognosis of Kawasaki disease, providing new treatment strategies and preventive measures. 【Key words】Platelet activating factor; Kawasaki disease; Prognosis; Pathogenesis; Treatment methods