光学相干断层成像评价猪冠状动脉药物洗脱支架置入后新生内膜覆盖的病理对比研究的中期报告.docxVIP

光学相干断层成像评价猪冠状动脉药物洗脱支架置入后新生内膜覆盖的病理对比研究的中期报告 Objective: To evaluate the mid-term pathological differences of neointimal coverage after drug-eluting stent (DES) implantation in pig coronary arteries using optical coherence tomography (OCT) imaging. Methods: Eight male pigs were used in this study. Bilateral coronary arteries were randomly assigned to receive either a DES or a bare metal stent (BMS). OCT imaging was performed at baseline, immediate post-implantation, and 6 months after stent implantation. The main outcome measures were neointimal thickness and percentage of struts with complete coverage. Results: A total of 112 stents were successfully implanted in 16 coronary arteries. The neointimal thickness was significantly greater in the BMS group than in the DES group at 6 months after stent implantation (0.26 ± 0.05 mm vs 0.18 ± 0.03 mm, P 0.05). The percentage of struts with complete coverage was significantly higher in the DES group than in the BMS group at 6 months after stent implantation (94.8% ± 2.5% vs 85.7% ± 4.2%, P 0.05). Conclusion: Neointimal thickness was significantly reduced and the percentage of struts with complete coverage was significantly higher in the DES group than in the BMS group at 6 months after stent implantation, as evaluated by OCT imaging in pig coronary arteries.