儿童神经影像诊断.pptVIP

儿童神经系统影像诊断 2012/03/18 主要内容儿童脑发育与髓鞘化癫痫影像检查感染性病变新技术弥散成像DWIMR波谱磁敏感成像SWI 新生儿脑组织含水量70%75%80%85%95%HIE T1T2FLAIRb 1000ADC“adult pattern” T1T2FLAIRDWIADCnewborn 髓鞘化:? [脂质] [水]“adult pattern”T1T2缩短 T1、 T2弛豫时间WWWWGGGGnewborn12 months24 months 髓鞘化的挨次PNS早于 CNS感觉早于运动原始功能区早于协同功能区尾侧到头侧，背侧到腹侧，中央到周围 胼胝体髓鞘化T1T2newborn T1T29 months胼胝体髓鞘化 4 months2.5 years胼胝体发育不良 Normal, 4 daysPLICvpl 100% have abnormal neurodevelopmental outcome [Rutherford MA et al, Pediatrics 1998] Normal, 4 daysSevere HIE, 4 daysPLICvpl@ 1 month NORMDEHSIDiffuse excessive white matter intensityMild HIE, 6 days 小结儿童脑与成人有明显区分，髓鞘化的信号变化有规律良