关于降脂药物汇总详解.pptVIP

The rate of occurrence of muscular symptoms with high dosage statin therapy varied depending on the statin Lescol? XL treatment was associated with a significantly lower risk of muscular symptoms compared with pravastatin, atorvastatin and simvastatin 他汀类药物 剂量 出现肌肉症状的比例 危险比? [95% CI] P 值? 普伐他汀 40 mg/天 10.9% 1 阿托伐他汀 40–80 mg/天 14.9% 1.28[1.02–1.60] 0.035 辛伐他汀 40–80 mg/天 18.2% 1.78[1.39–2.29] 0.0001 氟伐他汀 80 mg/天 5.1% 0.33[0.26–0.42] 0.0001 PRIMO研究:他汀类药物的剂量和肌肉症状的风险 Bruckert B et al.Cardiovascular Drugs and Therapy 2006；19：403-414 N=7924 当前第30页\共有54页\编于星期日\19点 PRIMO研究的启示 基于10%的发生率