离子液体催化合成嘧啶氨基酸酯类化合物.pdfVIP

第 45 卷第 1 期 化学试剂 CHEMICAL REAGENTS 163 离子液体催化合成嘧啶氨基酸酯类化合物 李熹2,李渺17魏娴1,柏松门 （1.贵州理工学院化学工程学院，贵州贵阳550003；2.贵州省煤田地质局实验室，贵州贵阳550008） 摘要 :以离子液体1-丁基-3-甲基咪唑氯盐 （［BMIM］Cl）为催化剂，合成了嘧啶氨基酸酯类化合物 。研究了不同的常规溶 剂和离子液体溶剂对嘧啶氨基酸酯类化合物产率的影响，以离子液体1-丁基-3-甲基咪唑漠盐 （［BMIM］Cl）为催化剂,在 温度为90 C的最优反应条件下一锅法合成了 8个嘧啶氨基酸酯衍生物（4a〜4h），具有较高的产率 （82%〜93%） 。通过 离子液体回收利用实验结果表明，重复使用5次后活性无明显下降，此外，生物活性测试结果表明,该类衍生物对猕猴桃 溃疡病菌、柑橘溃疡病菌、水稻白叶枯病菌具有一定的活性，其中,2-（（（5-氯-4-甲氧基-6-甲基嘧啶-2-基）氨基）（4-氯苯 基）甲基）丙二酸二乙酯对猕猴桃溃疡病菌、柑橘溃疡病菌、水稻白叶枯病菌活性分别为71. 5%、63. 0%、55. 4%,优于对 照药剂叶枯唑对3种病菌的抑制活性。 关键词 :嘧啶氨基酸酯 ;离子液体催化剂 ;合成 ;抗菌活性 ;精细化工中间体 中图分类号:O626 文献标识码 :A 文章编号：0258-3283（2023） 01-0163-06 D0I： 10.13822/j.cnki.hxsj.2022.0491 Catalytic Synthesis of Pyrimidine Amino Acid Ester Derivatives by Ion Liquid LI Xi2 ,LI Miao1 , WEI Xian1 ,BAI Song* 1 ( 1.School of Chemical Engineering,Guizhou Institute of Technology, Guiyang 550003, China； 2. Laboratory of Coalfield Geology Bureau of Guizhou Province,Guiyang 550008,China) Abstract ： Pyrimidine amino acid ester derivatives were synthesized by using ionic liquid 1-butyl-3-methylimidazolium chloride ( [ BMIM] Cl) as catalyst.The effects of different common solvents and ionic liquid solvents on the yield of pyrimidine amino acid ester derivatives were investigated. Eight pyrimidine amino acid ester derivatives (4a~4h) were synthesized by one-pot method u­ sing ( [ BMIM] Cl) as the catalyst under the optimal reaction conditions at 90 C .The reaction has high yield ( 82% ~ 93%) .The experimental result of ionic liquid recycling showed that the activity did not decrease significantly after repeated use for 5 times.In addition, the biological activity test results showed that the derivatives had certain activities against Pseudomonas syringae pv.ac- tinidiae ( Psa) ,Xanthomonas citri pv.citri (Xac) and Xanthomonas oryzae pv.oryzae (Xoo ). Among th