glp 1受体激动剂为t2dm解围参考文献jacc 2013研究.pdfVIP

Journal of the American College of Cardiology Vol. 62, No. 10, 2013 2013 by the American College of Cardiology Foundation ISSN 0735 1097/$36.00 Published by Elsevier . Body Fat Distribution, Cardiovascular Disease, Cancer, and All-Cause Mortality Kathryn A. Britton, MD, MPH,*y Joseph M. Massaro, PHD,z Joanne M. Murabito, MD, SCM,yx Bernard E. Kreger, MD,yx Udo Hoffmann, MD, MPH,k Caroline S. Fox, MD, MPHy{# Boston and Framingham, Massachusetts Objectives The aim of this study was to determine whether ectopic fat depots are prospectively associated with cardiovascular disease, cancer, and all cause mortality. Background The morbidity associated with excess body weight varies among individuals of similar body mass index. Ectopic fat depots may underlie this risk differential. However, prospective studies of directly measured fat are limited. Methods Participants from the Framingham Heart Study (n 3,086; 49% women; mean age of 50.2 years) underwent assessment of fat depots (visceral adipose tissue, pericardial adipose tissue, and periaortic adipose tissue) using multidetector computed tomography and were followed up longitudinally for a median of 5.0 years. Cox proportional hazards regression models were used to exam he association of each fat depot (per 1 SD rement) with the risk of cardiovascular disease, cancer, and all