杆状病毒介导以Dll4蛋白为靶点的癌症疫苗的研究的中期报告.docxVIP

杆状病毒介导以Dll4蛋白为靶点的癌症疫苗的研究的中期报告 Introduction: Dll4 is a ligand protein that is associated with cancer cell proliferation and angiogenesis. Therefore, Dll4 has become an attractive target for the development of cancer vaccines. This study aims to investigate the effectiveness of Dll4-targeted cancer vaccines mediated by adenovirus. Methods: In this study, we have utilized adenovirus-mediated Dll4 vaccine in BALB/c mice to investigate its efficacy in inducing T cell-mediated immune responses. Mice were immunized with adenovirus expressing Dll4 and boosted 2 weeks later. Control groups received ade