寰枢椎后路固定的三维有限元建模及生物力学分析的中期报告.docxVIP

寰枢椎后路固定的三维有限元建模及生物力学分析的中期报告 Abstract: Objectives: To perform a three-dimensional finite element modeling and biomechanical analysis of the posterior fixation of C1-C2 in order to evaluate the stability and safety of the fixation. Methods: CT and MRI data of the cervical spine of a healthy young adult were obtained for constructing models of C1-C2 complex, including ligaments, muscles, and spinal cord. The models were imported to Mimics and Abaqus software for image processing and finite element analysis. Different loading conditions, including flexion, extension, lateral bending, and axial rotation, were simulated to evaluate the stability and stress distribution of the fixation. Results: The three-dimensional finite element models of C1-C2 complex were successfully constructed, and four scenarios of loading conditions were simulated. The results showed that the fixation was stable under normal physiological loading, and the maximum stress occurred at the bone-screw interface. However, excessive axial rotation and lateral bending could cause the screws to loosen, which might lead to a loss of stability. Moreover, the spinal cord and surrounding tissues were not significantly affected during the whole loading process. Conclusions: The posterior fixation of C1-C2 complex is a safe and effective treatment for atlantoaxial instability. However, the screws should be placed accurately and size-matched to avoid loosening or shifting during excessive loading. Further research is needed to evaluate the long-term outcomes of this fixation technique. 摘要： 目的：进行C1-C2后路固定的三维有限元建模和生物力学分析，以评估固定的稳定性和安全性。 方法：使用一名健康年轻成人的颈椎CT和MRI数据，构建C1-C2复合体、包括韧带、肌肉和脊髓的模型。将模型导入Mimics和Abaqus软件进行图像处理和有限元分析。模拟不同的载荷条件，包括弯曲、伸展、侧弯和轴向旋转，来评估固定的稳定性和应力分布。 结果：成功构建了C1-C2复合体的三维有限元模型，并模拟了四种载荷情况。结果表明，在正常生理载荷下，固定是稳定的，最大应力发生在骨螺钉界面。然而，过度的轴向旋转和侧弯可能导致螺钉松动，从而导致稳定性丧失。此外，在整个载荷过程中，脊髓和周围组织并没有受到明显影响。 结论：C1-C2复合体的后路固定是治疗寰枢椎不稳定性的安全有效方法。然而，应用充分考虑螺钉的准确位置和大小匹配，以避免在过度载荷下松动或变位。需要进一步研究以评估此固定技术的长期效果。