有机还原剂在1，2-环氧化合物选择性开环反应中的研究的中期报告.docxVIP

有机还原剂在1，2-环氧化合物选择性开环反应中的研究的中期报告 摘要： 1，2-环氧化合物是一类重要的有机化合物，具有广泛的应用前景，因此，研究其选择性开环反应具有重要的理论和应用价值。本文通过文献调研，综述了有机还原剂在1，2-环氧化合物选择性开环反应中的研究进展，并结合作者进行的实验研究进行总结。 首先，介绍了1，2-环氧化合物的结构和性质特点，以及选择性开环反应的意义和目的。然后，总结了有机还原剂在1，2-环氧化合物选择性开环反应中发挥的作用，包括还原剂种类、反应条件、反应机理等方面的影响因素，以及在不同催化体系下的反应选择性和产率。同时，将有机还原剂的优缺点进行了分析和比较。 最后，结合作者实验室的研究工作，重点介绍了NaBH4-FeCl3催化剂体系在1，2-环氧化合物选择性开环反应中的应用和优点，探讨了反应机理，并比较了多种还原剂体系的反应效果。 关键词：1，2-环氧化合物；选择性开环反应；有机还原剂；催化剂体系。 Abstract: 1, 2-epoxides are an important class of organic compounds with wide applications. Therefore, the study of their selective ring-opening reactions is of great theoretical and applied value. In this paper, through literature review, the research progress of organic reducing agents in selective ring-opening reactions of 1, 2-epoxides is summarized, and the experimental research conducted by the authors is also discussed. Firstly, the structure and properties of 1, 2-epoxides and the significance and purpose of selective ring-opening reactions were introduced. Then, the role of organic reducing agents in selective ring-opening reactions of 1, 2-epoxides was summarized, including the influence factors of reducing agent type, reaction conditions, reaction mechanism, and the reaction selectivity and yield under different catalytic systems. Meanwhile, the advantages and disadvantages of organic reducing agents were analyzed and compared. Finally, the application and advantages of NaBH4-FeCl3 catalyst system in selective ring-opening reactions of 1, 2-epoxides were mainly introduced based on the research work of the authors laboratory. The reaction mechanism was also discussed, and the reaction effects of different reducing agent systems were compared. Keywords: 1, 2-epoxides; selective ring-opening reaction; organic reducing agents; catalyst system.