肉毒毒素与透明质酸联合治疗的安全性研究以及对真皮层胶原含量的影响的中期报告.docxVIP

肉毒毒素与透明质酸联合治疗的安全性研究以及对真皮层胶原含量的影响的中期报告 此报告的英文原文如下： Mid-term report on the safety study and the effect on dermal collagen content of combined treatment with botulinum toxin and hyaluronic acid Objective: To evaluate the safety and effect on dermal collagen content of combined treatment with botulinum toxin and hyaluronic acid. Methods: This was a randomized, placebo-controlled, double-blind study. A total of 30 female subjects with moderate to severe nasolabial folds were enrolled and evenly divided into three groups: group A (botulinum toxin and hyaluronic acid treatment), group B (botulinum toxin treatment only) and group C (placebo control). Treatment was conducted at baseline and at week 4. Safety assessment was performed at weeks 2, 4, 8 and 12. The effect on dermal collagen content was evaluated at baseline, week 4 and week 12 by skin biopsy and histological analysis. Results: There were no serious adverse events reported in any group. Transient mild to moderate erythema and swelling were reported in all groups, but these resolved within a few days. There was a significant increase in dermal collagen content in group A at week 12 compared to baseline (p0.05), but no significant change was observed in group B or group C. Conclusion: Combined treatment with botulinum toxin and hyaluronic acid is safe and well-tolerated. The treatment resulted in a significant increase in dermal collagen content at week 12, which suggests a potential benefit of this approach in preventing dermal collagen degradation. Further studies with larger sample sizes are needed to confirm these findings.