肿瘤血栓临床研究详解演示文稿.pptVIP

0 10 20 30 40 50 60 70 80 90 100 0 30 60 90 120 180 240 300 360 Dalteparin OAC HR 0.94 P-value = 0.40 Days Post Randomization Probability of Survival, % Lee AY et al. J Clin Oncol. 2005; 23:2123-9. CLOT研究：所有患者12月死亡率没有改善 本文档共34页；当前第29页；编辑于星期一\19点19分 LMWH对小细胞肺癌研究 84 patients randomized: CEV +/- LMWH (18 weeks) Patients balanced for age, gender, stage, smoking history, ECOG performance status Altinbas et al. J Thromb Haemost 2004;2:1266. Chemotherapyplus Dalteparin Chemo alone P-value 1-y overall survival, % 51.3 29.5 0.01 2-y overall survival, % 17.2 0.0 0.01 Median survival, m 13.