Migraine_偏头痛(中英双语版).pptxVIP

Migraine is manifested by headache that is a recurrence, usually unilateral and freque pulsatile in quali 性 ; it is often assoc with nausea, vomiting, photophobi phonophobia惧声 and lassitude乏力. Visual or other neurologic auras神经学先兆 occur in abou 10% of patients. The onset is early in life approximately 2 beginning during the first decade, 55% by 20 years of age, more than 90% before age 40. A.Cause and pathogen esis The real causes and the pathogenesis and pathophysio logic course of migraine is unknown. 1.Certain foods : 酪 tyramine 胺-containing hot dogs or bacon,with nitrite亚硝酸 preservatives, chocolate contain i but not chocolate alone. Food additives : monosodium glutamate谷氨酸一钠； Fasting禁食; Emotion情绪; Menses月经; Drugs :especially oral contraceptive agen vasodilators (nitri glycerin硝酸甘油) Brights lights may also trigger or precip attacks. 2. Genetics : About 60% patients of migrai have families . Three genetic loci for hemiplegic migraine（ 偏瘫型)have been identi 3. Endocrine factor 内分泌异常 Gender : women men (2/3 to 3/4 of cases occur in women) ; Headache mostly occu before or menacme月经期 in women , and the headache becomes reduction or stopping in pregnancy and after menopause绝经. The migraine also stops in men of 4. vasomotor and autonomic 血管运动和自律神经 Intracranial vasoconstriction and extracranial vasodilatation have long been held to be the respective causes of the aura and headache phases of migraine. But the study of CBF脑血流 can ’t confirm. 5. spreading depression 扩布性抑制 More recent studies of rCBF局部脑血流 during migraine attacks have demonstrated a reduction in regional flow, which begins in the occipital