动物模型作为治疗反应预测因子价值国讲稿.pdfVIP

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动物模型作为治疗反应预测因子价值国讲稿.pdf

Valueofanimalmodelsaspredictorsof

responsetoPAHtreatments

LanZhao(UK)

RoleofanimalmodelsinPHresearch

•Toidentifynewdrugtargets

•Tovalidatenewdrugtargets

•Toexploreefficacy

•Toexplorethesafetyprofileofnew

medications

Pulmonaryhypertension

▪Abnormalpulmonaryvasoconstriction

▪Pulmonaryvascularremodelling

▪Rightventricularhypertrophy

DenovoMuscularization/distalMigration

normal

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