土壤多环芳烃生物可给性测定的体外胃肠模拟法研究进展.pdf

土壤(Soils),2023,55(6):1161–1169

DOI:10.13758/ki.tr.2023.06.001

马俊超,高彦征,秦超.土壤多环芳烃生物可给性测定的体外胃肠模拟法研究进展.土壤,2023,55(6):1161–1169.

土壤多环芳烃生物可给性测定的体外胃肠模拟法研究进展①

马俊超，高彦征，秦超*

(南京农业大学土壤有机污染控制与修复研究所，南京210095)

摘要：经口摄入是土壤多环芳烃(PAHs)人体暴露的重要途径，有效评估土壤中PAHs的生物可给性是全面评估土壤PAHs人体健

康风险的重要组成部分。然而，测定土壤PAHs生物可给性的体外胃肠模拟方法众多，至今国内外尚缺乏统一标准。由于不同体外

模拟方法测定的结果差异较大，制约了土壤PAHs人体健康风险评估的发展。基于此，本文综述了PAHs生物可给性测定所用的多

种体外胃肠模拟方法及进展，并针对PAHs生物可给性测定方法存在的问题，建议未来构建土壤PAHs生物可给性测定标准方法的

相关研究应从生理条件、吸附材料的选择、体内模型的验证这3方面综合考虑。

关键词：有机污染物；PAHs；体外胃肠模拟；生物有效性；人体健康风险评估

中图分类号：X-1文献标志码：A

AdvancesofinvitroGastrointestinalSimulationMethodsforDeterminingBioaccessibilityof

PolycyclicAromaticHydrocarbons(PAHs)inSoil

*

MAJunchao,GAOYanzheng,QINChao

(InstituteofOrganicContaminantControlandSoilRemediation,NanjingAgriculturalUniversity,Nanjing210095,China)

Abstract:Oralingestionisanimportantrouteofhumanexposedtosoilpolycyclicaromatichydrocarbons(PAHs).Effective

assessmentofthebioaccessibilityofPAHsisanimportantcomponentofacomprehensiveassessmentofthehumanhealthriskof

PAHsinsoil.However,therearemanyinvitrogastrointestinalsimulationmethodstoevaluatethebioaccessibilityofsoilPAHs,

andthereisstillnouniformstandardinChinaaswellasabroad.ThedevelopmentofhumanhealthriskassessmentofsoilPAHs

hasbeenhamperedbythelargevariationintheresultsofdifferentinvitrosimulationmethods.Thus,thispaperreviewedvarious

invitrogastrointestinalsimulationmethodsandtherelatedadvancesforPAHsbioavailabilitydetermination,andsuggestedthat

futureresearchontheconstructionofstandardmethodsforPAHsbioaccessibilitydeterminationinsoilsshouldbebasedonthree

aspects:physiologicalconditions,selectionofadsorbentmaterials,andvalidationofinvivomodels.

Keywords:Organicpo