紫杉醇减少脊髓损伤后疤痕形成并促进轴突再生.pptxVIP

Title：MicrotubuleStabilizationReducesScarringandCausesAxon

RegenerationAfterSpinalCordInjury

FaridaHellaletal.Science331,928(2011);DOI:10.1126/science.1201148Reporter:***Supervisor:***SecondarySupervisor:***

BackgroundsHypertrophicscarringandpoorintrinsicaxongrowthcapacityconstitutemajorobstaclesforspinalcordrepair.Microtubuledynamicsregulatekeyprocessesduringscarring,includingcellproliferation,migration,anddifferentiationaswellasintracellulartraffickingandsecretionofextracellularmatrix(ECM)molecules(1,2).Moreover,moderate