Gefitinib-Standard-ZD1839-Standard-DataSheet-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

Gefitinib(Standard)

Cat.No.:HY-50895R

CASNo.:184475-35-2

Synonyms:ZD1839(Standard)

分⼦式:C₂₂H₂₄ClFN₄O₃

分⼦量:446.9

作⽤靶点:EGFR;Autophagy;Apoptosis

作⽤通路:JAK/STATSignaling;ProteinTyrosineKinase/RTK;

Autophagy;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

溶解性数据

体外实验DMSO:100mg/mL(223.76mM;Needultrasonic)

Mass

Solvent

1mg5mg10mg

Concentration

制备储备液1mM2.2376mL11.1882mL22.3764mL

5mM0.4475mL2.2376mL4.4753mL

10mM0.2238mL1.1188mL2.2376mL

BIOLOGICALACTIVITY

⽣物活性Gefitinib(Standard)是Gefitinib的分析标准品。本产品⽤于研究及分析应⽤。Gefitinib(ZD1839)是⼀种有

效，选择性和⼝服活性的EGFR酪氨酸激酶抑制剂，IC50为33nM。Gefitinib选择性抑制EGF刺激的肿瘤细

胞⽣长(IC50为54nM)，并阻断EGF刺激的肿瘤细胞中EGFR⾃磷酸化。Gefitinib还可诱导细胞⾃噬(