LXQ-217-DataSheet-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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LXQ-217

Cat.No.:HY-161360

CASNo.:2524718-79-2

分⼦式:C₂₄H₂₀Br₂N₂O₅

分⼦量:576.23

作⽤靶点:SHP2;Apoptosis

作⽤通路:ProteinTyrosineKinase/RTK;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性LXQ-217是⼀种⼝服活性SHP2抑制剂，其IC50值为2.01μM。LXQ-217在诱导细胞凋亡(apoptosis)，在体

内外抑制细胞⽣长。

体外研究LXQ-217(72h)inhibitscellgrowthofA549,HCT116,HepG2andMDA-MB-231cellswiththeIC50valuesof

2.06,3.88,4.53,and5.13μM[1].

LXQ-217(2.5,5,10μM,7days)decreasestheclonogenicnumberandformationrateofA549cells[1].

LXQ-217(1.25,2.5μM,24h)inhibitsthemigrationofA549cells[1].

LXQ-217(2.5,5,10μM,3h)increasesinthelevelscleaved-parp(C-parp),cleaved-caspase9(C-cas9)and

cleaved-caspase3(C-cas3)inA549cells[1].

CellMigrationAssay[1]

CellLine:A549cells

Concentration:1.25and2.5μM

IncubationTime:72h

Result:InhibitedthemigrationofA549cells.

WesternBlotAnalysis[1]

CellLine: