CTLA-4基因多态性与结直肠癌易感性的关联研究开题报告.docxVIP

CTLA-4基因多态性与结直肠癌易感性的关联研究开题报告

摘要

结直肠癌是一种常见的消化道肿瘤，其发生率逐年增加，成为临床上较为常见的恶性肿瘤之一。CTLA-4是T细胞免疫调节关键分子，其基因多态性与多种自身免疫疾病及肿瘤患病风险增加有关。本研究旨在探讨CTLA-4基因多态性与结直肠癌易感性的关联。

首先，通过检索相关文献和数据库，收集与CTLA-4基因多态性和结直肠癌的关联研究，并进行筛选和分析。其次，选取符合纳入标准的研究进行meta分析，计算OR值和95%的CI值，并绘制森林图。最后，对结果进行稳健性分析和亚组分析。

预计结果：CTLA-4基因多态性与结直肠癌易感性具有一定的关联性，可能成为结直肠癌的潜在风险因素。

关键词：CTLA-4；基因多态性；结直肠癌；易感性；meta分析。

Abstract

Colorectalcancerisacommondigestivetracttumorwithanincreasingincidenceinrecentyears,becomingoneofthecommonmalignanttumorsinclinicalpractice.CTLA-4isacrucialmoleculeinT-cellimmuneregulation,anditsgeneticpolymorphismisassociatedwithanincreasedriskofvariousautoimmunediseasesandtumors.ThisstudyaimstoexploretheassociationbetweenCTLA-4genepolymorphismandsusceptibilitytocolorectalcancer.

First,wesearchedrelevantliteratureanddatabases,collectedstudiesontheassociationbetweenCTLA-4genepolymorphismandcolorectalcancer,andthenscreenedandanalyzedthem.Second,weselectedstudiesthatmettheinclusioncriteriaformeta-analysis,calculatedtheORvalueand95%CIvalue,anddrewaforestplot.Finally,weconductedrobustnessanalysisandsubgroupanalysisoftheresults.

Expectedresults:CTLA-4genepolymorphismisassociatedwithsusceptibilitytocolorectalcancerandmaybecomeapotentialriskfactorforcolorectalcancer.

Keywords:CTLA-4;genepolymorphism;colorectalcancer;susceptibility;meta-analysis.