HPLC用MWNTs淀粉衍生物类CSPs的研究的开题报告.docxVIP

HPLC用MWNTs淀粉衍生物类CSPs的研究的开题报告

Title:StudyonMWNTs-StarchDerivative-BasedChiralStationaryPhasesforHPLC

Introduction:

Currently,thedemandforhigh-resolutionandefficientanalysisofchiralcompoundsindifferentfieldssuchasbiomedicine,pharmaceutical,andfoodindustriesisincreasing.High-performanceliquidchromatography(HPLC)isacommonlyusedtechniqueforseparatingchiralcompounds.Chiralstationaryphases(CSPs)isacrucialfactorthatdeterminestheresolutionofchiralcompounds.Therefore,developingnewCSPswithbetterperformanceishighlydesired.Carbonnanotubes(CNTs)isapromisingmaterialthathasbeenwidelyusedasasupportfordifferentCSPs.Inthisstudy,weaimtosynthesizeCSPsbasedonMWNTs-starchderivativesandevaluatetheirperformanceforHPLCseparationofchiralcompounds.

Objectives:

1.SynthesizeMWNTs-starchderivativesaschiralstationaryphases(CSPs).

2.EvaluatetheperformanceofCSPsusingHPLCtoseparatechiralcompounds.

3.OptimizetheseparationconditionsfortheMWNTs-starchderivative-basedCSPs.

4.ComparetheperformanceofMWNTs-starchderivative-basedCSPswithexistingCSPs.

Methodology:

1.SynthesizeMWNTs-starchderivativesbyoxidizingMWNTsandgraftingthemwithstarchderivatives.

2.CharacterizethesynthesizedMWNTs-starchderivativesusingFT-IR,Ramanspectroscopy,thermalgravimetricanalysis(TGA),andscanningelectronmicroscopy(SEM).

3.EvaluatetheperformanceofCSPsusingHPLCtoseparateaseriesofchiralanalytessuchasaminoacids,pharmaceuticals,andfoodadditives.

4.Optimizetheseparationconditionssuchasmobilephasecomposition,pH,andtemperature.

5.ComparetheperformanceofMWNTs-starchderivative-basedCSPswithcommercialCSPsandotherCNT-basedCSPs.

ExpectedOutcomes:

1.SuccessfulsynthesisofMWNTs-starchderivative-basedCSPs.

2.ImprovedchiralseparationefficiencyandresolutioncomparedtoexistingCSPs.

3.Optimizationofseparationcond