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HOWMAMMALSSENSEINFECTION:FROM

ENDOTOXINTOTHETOLL-LIKERECEPTORS

NobelLecture,December7,2011

by

BRUCEBEUTLER

CenterforGeneticsofHostDefense,theUniversityofTexasSouthwestern

MedicalCenter,Dallas,TX,USA.

HOWICAMETOWORKONTHEQUESTION

OFINNATEIMMUNESENSING

About30yearsafterthefact,Irememberedawalkmyfather(Figure1)and

ItookthroughagroveofredwoodsinSequoiaNationalPark.Iwasperhaps

10or12yearsofage.“Whyisitthattreesdon’tsimplyrot?”Iaskedhim,

awarethatplantshadnoneofthelymphoidormyeloidcellsthatconfer

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