4-(乙酰氨基)环己酮的制备.pdf

4-(乙酰氨基)环己酮的制备

英文回答：

Preparationof4-(acetylamino)cyclohexanone.

4-(acetylamino)cyclohexanoneisaversatile

intermediateinthesynthesisofvariouspharmaceuticals

andfinechemicals.Itcanbepreparedbyseveralmethods,

including:

1.Reactionofcyclohexanonewithacetamide.

Thisisthemoststraightforwardmethodforpreparing

4-(acetylamino)cyclohexanone.Cyclohexanoneisreactedwith

acetamideinthepresenceofaLewisacidcatalyst,suchas

aluminumchlorideorzincchloride.Thereactionproceeds

viaanelectrophilicaromaticsubstitutionmechanism,with

theacetamidenitrogenatomattackingtheelectrophilic

carbonofthecyclohexanonering.

2.Reductionof4-(nitroacetyl)cyclohexanone.

4-(nitroacetyl)cyclohexanoneisaprecursorto4-

(acetylamino)cyclohexanone.Itcanbepreparedbyreacting

cyclohexanonewithnitroacetylchloride.Thenitrogroup

canthenbereducedtotheaminogroupusingavarietyof

reducingagents,suchashydrogengasinthepresenceofa

palladiumcatalystorsodiumborohydride.

3.Aminationof4-chlorocyclohexanone.

4-chlorocyclohexanonecanbeconvertedto4-

(acetylamino)cyclohexanonebyreactingitwithammoniain

thepresenceofapalladiumcatalyst.Thereactionproceeds

viaanucleophilicaromaticsubstitutionmechanism,with

theammonianitrogenatomattackingtheelectrophilic

carbonofthecyclohexanonering.

4.Cyclizationof6-aminohexanoicacid.

6-aminohexanoicacidcanbecyclizedtoform4-

(acetylamino)cyclohexanonebyheatingitinthepresenceof

aceticanhydride.Thereactionproceedsviaan

intramolecularnucleophilicacylsubstitutionmechanism,

withtheaminogroupofthe6-aminohexanoicacidattacking

thecarbonylgroupoftheaceticanhydride.

中文回答：

4-(乙酰氨基)环己酮的制备。

4-(乙酰氨基)环己酮是多种药物和精细化学品合成中的重要中

间体。它可以通过多种方法制备，包括：

1.环己酮与乙酰胺的反应。

这是制备4-(乙酰氨基)环己酮最直接的方法。环己酮在路易斯

酸催化剂（如氯化铝或氯化锌）的存在下与乙酰胺反应