观察高龄夫妇的生育能力及相关影响因素.doc

观察高龄夫妇的生育能力及相关影响因素

摘要：目的：观察高龄夫妇生育能力，及影响生育能力的因素。方法：随机选取2016年1月至2018年6月于我中心行孕前优生检查的600对育龄夫妇，作为对象展开临床分析。根据年龄分组：高龄夫妇组（女方年龄≥35岁，男方年龄≥40岁）300对，适龄组（女方年龄≥20岁，＜35岁，男方年龄≥20岁，＜40岁）300对。对所有夫妇实施国家免费孕前优生检查项目及免费地中海贫血干预项目。结果：两组在受孕结果的比较，有明显差异（P＜0.05）。两组在前置胎盘的风险因素对比无统计意义（P＞0.05）；两组在地中海贫血、自然流产、孕产期并发症等风险因素的对比，有明显差异（P＜0.05）。地中海贫血史、自然流产≥2次、孕期高血压、孕期糖尿病，是影响高龄夫妇生育能力的独立危险因素（P＜0.05）。两组在妊娠结果的对比差异显著（P＜0.05）。结论：夫妇年龄的高低对自然受孕率有较大的影响，影响高龄夫妇生育能力的因素较多，包括地中海贫血、自然流产史、孕期并发症等，且高龄夫妇生育的缺陷儿和早产儿概率更高。

关键词：高龄夫妇；生育能力；调查；影响因素；妊娠期并发症

Analysisoffertilityandrelatedinfluencingfactorsofseniorcouples

Abstract:objective:toobservethefertilityofelderlycouplesandthefactorsaffectingfertility.Methods:600couplesofchildbearingagewhowererandomlyselectedfromJanuary2016toJune2018forpre-pregnancyeugenicsexaminationinourcenterwereselectedforclinicalanalysis.Accordingtotheagegroup,therewere300pairsintheseniorcouplegroup(female35yearsold,male40yearsold)and300pairsintheschool-agegroup(female20yearsold,35yearsold,male20yearsold,40yearsold).Thenationalfreepre-pregnancyeugenicsexaminationprogramandfreethalassemiainterventionprogramwereimplementedforallcouples.Results:thereweresignificantdifferencesbetweenthetwogroups(P0.05).Therewasnostatisticalsignificanceinthecomparisonofriskfactorsofplacentapreviabetweenthetwogroups(P0.05).Thereweresignificantdifferencesbetweenthetwogroupsinriskfactorssuchasthalassemia,spontaneousabortion,andcomplicationsduringpregnancy(P0.05).Historyofthalassemia,spontaneousabortionmorethan2times,hypertensionduringpregnancy,andgestationaldiabetesmellituswereindependentfactorsfornosocomialinfectioninchildrenwithurinarysurgery(P0.05).Thedifferenceinpregnancyoutcomebetweenthetwogroupswassignificant(P0.05).Conclusion:theageofcoupleshasagreatinfluenceonthenaturalpregnancyrate.Therearemanyfactors