- 1、本文档共22页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
HierarchicalBayesianModelSpecificationModelisspecifiedbytheDirectedAcyclicNetwork(DAG)andtheconditionalprobabilitydistributionsofallnodesgivenvaluesofitsparentsTopologyoftheDAGdefinestheconditionaldependenciesofallvariablesthroughtheMarkovdirectedMarkovpropertywhichstatesthatgiventhevaluesofitsparents,avariableinthemodelisindependentofallitsnon-descendentsDAGandlocaldistributionsdefinethejointprobabilitydistributionofdataandallparametersinthemodelInourcasethisdistributioncannotbeexplicitlycharacterizedbutitestimatesusingMarkovChainMonteCarloapproach(Gibbssampler)
UsesandMiss-UsesofClusteringDefineastatisticalmodelthatfacilitatesclusteringofgenesbasedonsimilaritiesoftheirexpressionprofilesDefinethemethod-selectioncriteriathatallowsforestimatingthecorrectnumberofclustersShowthatinappropriatepre-filteringcanfoolthestatisticalmodelinthesamewayitfoolsthecasualobserverShowappropriatewaystouseclusteranalysisandillustratetheimportanceofusingthebestavailabletreatment
Clusteringofgeneexpressionprofiles
“Patterns”ofExpression-FiniteMixtureModelPatterni??i=(?1i,?2i,…,?11i)Dataik~iidN(?i,?),k=1,…,nini=numberofgenesgeneratedbythePatterni?i=ni/n
“Patterns”ofExpression-FiniteMixtureModelAnygeneprofilex=(x1,x2,…,x11)?Alldatax1,x2,…,xn}FiniteMixtureModel
One-dimensionalmixturePattern1Pattern2N(?11,?)N(?12,?)
MCLUSTlibrary(mclust)SimData-matrix(rnorm(5000*15),ncol=15)ColLabels-c(paste(Tumor_,1:8,sep=),paste(Control_,1:7,sep=))heatmap(SimData,labCol=ColLabels).Mclust$hcModelNames-c(E,EEI).Mclust$emModelNames-c(EEI)BIC.emclust-EMclust(SimData,1:10)BIC.emclustBIC:EEI1-213490.32-213624.93-213753.04-213880.75-213993.76-214121.07-214243.48-214351.69-214481.410-214588.7plot(BIC.emclust)EEI1
Determiningthenumberofpatterns
MCLUSTp.
文档评论(0)