不明原发灶肿瘤的诊断ed专家讲座.pptVIP

MetastaticCancerUnknownPrimarySite中国医学院肿瘤医院内科王宏羽不明原发灶肿瘤的诊断ed专家讲座第1页

MetastaticCancer

UnknownPrimarySite

Synonymsandrelatedkeywords◆tumorofunknownprimary◆cancerofunknownorigin◆carcinomaofunknownorigin◆unknownprimarycancer不明原发灶肿瘤的诊断ed专家讲座第2页

MetastaticCancer

UnknownPrimarySite

◆unknownprimarycarcinoma◆carcinomaofunknownprimaryorigin不明原发灶肿瘤的诊断ed专家讲座第3页

MetastaticCancer

UnknownPrimarySite

◆cancerofunknownprimarysite(cups)◆carcinomaofunknownprimaryorigin(CUP)不明原发灶肿瘤的诊断ed专家讲座第4页

MetastaticCancer

UnknownPrimarySite

◆metastaticcancer◆metastaticcarcinoma◆metastatictumor◆metastases◆occultprimarymalignancy不明原发灶肿瘤的诊断ed专家讲座第5页

CUP

Background(intheUnitedStates)◆32,100patswithCUPSin(15,720males;16,380females)◆About2%ofallcancers不明原发灶肿瘤的诊断ed专家讲座第6页

CUP

◆DeathsduetoCUPS:45,230(24,440males;20,790females)不明原发灶肿瘤的诊断ed专家讲座第7页

CUP◆Thisdiscrepancybetweenincidenceandmortalityisbelievedtobeduetoalackofspecificityinthelistingof?causeofdeathondeathcertificates不明原发灶肿瘤的诊断ed专家讲座第8页

CUP

◆Itstrueincidenceismostprobablybetween2%and6%◆In15-25%ofcases,theprimarysitecannotbeidentifiedevenonpostmortem不明原发灶肿瘤的诊断ed专家讲座第9页

CUP

Pathophysiology◆Cancersarethoughttoarisefromasinglecellthatescapesthecontrolsofnormalcellreplication◆Formsatumoratthesiteoforigin◆Ultimatelymetastasizestootherorgans不明原发灶肿瘤的诊断ed专家讲座第10页

CUP

Pathophysiology◆Insomecasestheoriginaltumormayremainsmallorundetectableatthetimeofmetastasis◆LeadingtotheclinicalpresentationofCUP不明原发灶肿瘤的诊断ed专家讲座第11页

CUPFrequency◆UnitedStates:2-6%?◆International:2-9%不明原发灶肿瘤的诊断ed专家讲座第12页

CUPMortality/Morbidity◆Mediansurvival?rangesfrom11weeksto11months◆The5-yearoverallsurvivalrateisabout11%不明原发灶肿瘤的诊断ed专家讲座第13页

CUPSex◆Anapproximate