β内酰胺类抗生素课件.pptx

β内酰胺类抗生素ppt课件汇报人：xxx

β内酰胺类抗生素概述β内酰胺类抗生素分类β内酰胺类抗生素药理作用β内酰胺类抗生素临床应用β内酰胺类抗生素研究进展总结与展望目录

01β内酰胺类抗生素概述

β-内酰胺类抗生素是指化学结构中具有β-内酰胺环的一大类抗生素，通过干扰细菌细胞壁的合成而发挥抗菌作用。定义β-内酰胺类抗生素与细菌细胞膜上的青霉素结合蛋白（PBPs）结合，抑制细菌细胞壁的合成，导致细菌细胞壁缺损，水分渗入菌体，使菌体膨胀、裂解、死亡。同时，β-内酰胺类抗生素还可触发细菌细胞壁的自溶酶活性，使细菌自溶或细胞壁水解。作用机制定义与作用机制

自1928年青霉素被发现以来，β-内酰胺类抗生素经历了近一个世纪的发展。从最初的青霉素，到后来的头孢菌素、头霉素类、硫霉素类等，β-内酰胺类抗生素的种类不断增加，抗菌谱和抗菌作用也不断扩大。发展历程目前，β-内酰胺类抗生素已成为临床最常用的抗菌药物之一。随着细菌耐药性的不断增加，新型β-内酰胺类抗生素的研究和开发也在不断深入，为临床治疗提供了更多的选择。现状发展历程及现状

以下附赠各项管理制度英文版（不需要可删）急救药品、器材管理制度:1.Rescuedrugsandequipmentshouldbefivefixed(fixedquantityandvariety,designatedplacement,designatedpersonstorage,regulardisinfectionandsterilization,regularinspectionandmaintenance)andtwotimely(timelyinspectionandmaintenance,timelyreceiptandsupplementation).Theitemisclearlymarkedandcannotbeusedarbitrarily.2.Thenecessaryrescueequipmentiscomplete,ingoodperformance,andinstandbycondition.3.Therescuedrugsarecomplete,withcleardruglabelsandnodiscoloration,deterioration,expiration,ordamage.Theyshouldbeplacedandusedintheorderofdrugexpirationdates(fromrighttoleft).4.Emergencydrugsanditemsforeachdepartmentsrescuevehicleshallbeuniformlyequippedaccordingtorequirements.Specializedemergencydrugsanditemsmustbereviewedandapprovedbythedepartmentdirectortodeterminethetype,quantity,specifications,anddosagetobeequipped.Rescuevehiclesmustbeplacedindesignatedlocationsandmanagedbydesignatedpersonneltoensuresafetyandeaseofuse.5.Afterusingrescuedrugsandequipment,theyshouldbefullyreplenishedwithin24hours.Iftheycannotbereplenishedduetospecialreasons,theyshouldbenotedonthehandoverregistrationformandreportedtotheheadnurseforcoordinationandresolutiontoensuretimelyuseduringpatientrescue.6.Thereisaregistrationbookfortheprovisionofdrugsandequipment.Ensureconsistencybetweenaccountsandmaterials,and