型糖尿病青少肥胖问题1591-s2 main.pdfVIP

ObesityinYouthwithType1DiabetesinGermany,Austria,andthe

UnitedStates

12314

StephanieN.DuBose,MPH,JuliaM.Hermann,MS,WilliamV.Tamborlane,MD,RoyW.Beck,MD,PhD,AxelDost,MD,

5627,

LindaA.DiMeglio,MD,MPH,KarlOtfriedSchwab,MD,ReinhardW.Holl,MD,SabineE.Hofer,MD*,

andDavidM.Maahs,MD,PhD8,*,onbehalfofthe

Type1DiabetechangeClinicNetworkandDiabetesProspectiveFollow-upRegistry†

ObjectiveToexaminethecurrentextentoftheobesityproblemin2largepediatricclinicalregistriesintheUSand

Europeandtoexaminethehypothesesthatincreasedbodymassindex(BMI)z-scores(BMIz)areassociatedwith

greaterhemoglobinA1c(HbA1c)andincreasedfrequencyofseverehypoglycemiainyouthwithtype1diabetes(T1D).

StudydesignInternational(WorldHealthOrganization)antional(CentersforDiseaseControlandPrevention/

GermanHealthInterviewandExaminationSurveyforChildrenandAdolescents)BMIreferenceswereusedto

calculateBMIzinparticipants(age2-18yearsand$1yeardurationofT1D)enrolledintheT1DE

(n=11435)andtheDiabetesProspectiveFollow-up(n=21501).AssociationsbetweenBMIzandHbA1candse-

verehypoglycemiawereassessed.

ResultsParticipantsinbothregistrieshadmedianBMIvaluesthatweregreaterthaninternationalandtheir

respectivenationalreferencevalues.BMIzwassignificantlygreaterintheT1DE