依托考昔和美洛昔康治疗急性痛风的疗效和安全性.docx

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依托考昔和美洛昔康治疗急性痛风的疗效和安全性

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（青海省人民医院糖尿病科810001）

【摘要】目的：讨论研究应用依托考昔与美洛昔康用于治疗急性痛风的临床疗效与意义，并总结药物对患者的安全性。方法：选取我院风湿科科急性痛风患者100例。随机分组为A、B两组。A组患者使用依托考昔进行治疗；B组患者应用美洛昔康对其进行治疗。比较两组患者不同治疗后总有效率、不良反应等指标。结果：不同药物治疗后总有效率比较B组患者应用火针点刺放血疗法联合中医护理进行治疗总有效率为100%显著高于使用常规治疗方法患者总有效率90%（P＜0.05）。治疗后不良反应发生人数比较显示A组患者使用依托考昔治疗后各类不良反应发生人数均显著少于使用美洛昔康患者（P＜0.05）。结论：临床通应用依托考昔与美洛昔康治疗急性痛风均有显著疗效。依托考昔能够在短时间内缓解患者疼痛症状且吸收迅速。治疗后不良反应较少，安全系数高，患者依从性及耐受性较好，能够显著提高疾病治疗效率并加快患者速度，对促进其预后并改善生活质量具有重要意义。

【关键词】依托考昔；美洛昔康；急性痛风；临床疗效与安全性

R453A2095-1752（2015）29-0071-03

【Abstract】ObjectiveDiscussiononApplicationofetoricoxibandmeloxicamforclinicalcurativeeffectandthesignificanceofthetreatmentofacutegoutyarthritis,andconcludesonthesafetyofmedication.MethodsAtotalof100patientsinourhospitalwithacutegoutrheumatismkoko.WererandomlypidedintoA,Btwogroups.PatientsingroupAwithetoricoxibtreatment;groupBpatientsofmeloxicamtreatmentonit.Comparedtwogroupsofpatientswithdifferenttreatmentafterthetotalefficiency,adversereactionsandotherindicators.ResultsDifferentdrugtreatmentafterthetotalefficiencycomparedwiththeBgroupofpatientswithfireneedleprickingbloodtherapycombinedwithtraditionalChinesemedicinenursingtreatmentthetotaleffectiveratewas100%,significantlyhigherthanthatofpatientswithconventionaltreatmentthetotaleffectiveratewas90%(P0.05).Aftertreatment,numberofadversereactionscomparedAgroupwithetoricoxibtreatmentofadversereactionsaftertheoccurrenceofvariousnumbersweresignificantlylessthantheuseofmeloxicampatients(P0.05).ConclusionClinicalapplicationofetoricoxibandmeloxicamintreatmentofacutegouthasnotablecurativeeffect.Etoricoxibinashorttimecanrelievepainandrapidabsorption.Adversereactionaftertreatmentisless,highsafetycoefficient,thecomplianceofpatientsandwelltolerated,cansignificantlyimprovethetreatmentefficiencyandacceleratethespeedofdiseasepatients,topromotetheirprognosisandimprovethequalityoflifehasimportantsignificance.

【Keywords】Etoricoxib;Meloxicam;Acutegout;Theclinicalcurativeeffectandsafety

痛风是人体嘌呤代谢发生紊乱所导致的疾病，近年来发病人数较往年显著增加。本病急性发作