2型糖尿病患者颈动脉及下肢动脉硬化与冠状动脉疾病的关系.pdfVIP

2型糖尿病患者颈动脉及下肢动脉硬化与冠状动脉疾病的关系

【摘要】目的分析2型糖尿病合并冠心病的危险因素及其与颈动脉及下肢

动脉粥样硬化的相关性。方法将200例2型糖尿病患者分为冠心病组及非冠心

病组，均接受颈动脉及下肢动脉血管彩超检查，并记录两组临床资料及实验室数

据，分析冠心病的危险因素及与动脉粥样硬化的关系。结果①单因素分析发现

年龄、病程、收缩压、总胆固醇、尿素氮、肌酐、尿微量白蛋白、24h尿总蛋白、

高血压病史及脑梗死史，以及颈动脉、下肢动脉粥样硬化与糖尿病合并冠心病的

发病呈正相关，P＜0.05。②多因素分析提示颈动脉及下肢动脉粥样硬化是糖尿

病合并冠心病的独立危险因素，其OR值分别为1.841(95%CI:1.117,3.033)和

2.409(95%CI:1.659,3.497)。结论颈动脉及下肢动脉粥样硬化与2型糖尿病合并

冠心病密切相关，其预测冠心病能力较传统危险因素强。

【Abstract】ObjectiveToanalyzetheriskfactorsofcoronaryheartdisease

(CHD)withtype2diabetesmellitus,andtoexploretherelationshipbetweencarotid

artery,lowerlimbsarteryatherosclerosisandcoronarydisease.Methods200patients

withtype2diabetesmellitusweredividedintoCHDgroupandnonCHDgroup,and

acceptedthecarotidarteryandlowerlimbsarterialcolorDopplarultrasound

examination.Twogroupsofclinicaldataandlaboratorydatawererecorded,to

analyzetheriskofCHDfactorsandtherelationshipwithatherosclerosis.Results①

Singlefactoranalysisfoundthatage,duration,systolicbloodpressure,total

cholesterol,ureanitrogen,serumcreatinine,urinealbumin,24hurinetracetotal

protein,historyofhypertension,cerebralinfarctionhistory,andthecarotidartery,

lowerlimbsarteryatherosclerosiswerepositivelyrelatedwithCHDcombinedwith

diabetes,P＜0.05.②Multivariateanalysisshowedthatcarotidandlowerlimbs

atherosclerosisareindependentriskfactorsforCHDwithdiabetes,theORvalues

were1.841(95%CI:1.117,3.033)and2.409(95%CI:1.659,3.497).Conclusion

Carotidarteryandlowerlimbsatherosclerosisiscloselyrelatedwithdiabetesmellitus

withCHD,whichoftheforecastingabilityforCHDisstrongerthanthetraditional

riskfactors.

【Keywords】Diabetesmellitus;Atherosclerosis;Coronarydisease;

Ultrasonography;ColorDoppler

近年来研究表明，颈动脉粥样硬化(CA