BGC-20-1531-PGN-1531-生命科学试剂-MCE.pdf

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BGC-20-1531

Cat.No.:HY-W394717

CASNo.:1186532-61-5

Synonyms:PGN1531

分⼦式:C₂₆H₂₃N₂NaO₆S

分⼦量:514.53

作⽤靶点:ProstaglandinReceptor;PKA

作⽤通路:GPCR/GProtein;StemCell/Wnt;TGF-beta/Smad

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性BGC-20-1531(PGN1531)，⼀种苯磺酰胺衍⽣物，是⼀种选择性的EP4拮抗剂。BGC-20-1531结合PGE2，增

强ATP酶活性，与Gs蛋⽩偶联，从⽽激活腺苷酸酰化酶⽣成cAMP并激活PKA。BGC-20-1531有望⽤于肝脏

疾病的研究[1][2]。

IC50TargetEP4

REFERENCES

[1].AmmazzalorsoA,etal.N-acylsulfonamides:Syntheticroutesandbiologicalpotentialinmedicinalchemistry.ChemBiolDrugDes.2017

Dec;90(6):1094-1105.

[2].HodeifyR,etal.PGE2upregulatestheNa+/K+ATPaseinHepG2cellsviaEP4receptorsandintracellularcalcium.PLoSOne.2021

Jan14;16(1):e0245400.

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