Sarizotan-dihydrochloride-EMD-128130-dihydrochloride-生命科学试剂-MCE.pdf

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Sarizotandihydrochloride

Cat.No.:HY-100820B

CASNo.:177976-12-4

Synonyms:EMD128130dihydrochloride

分⼦式:C₂₂H₂₃Cl₂FN₂O

分⼦量:421.34

作⽤靶点:5-HTReceptor;DopamineReceptor

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Sarizotandihydrochloride(EMD128130)是具有⼝服活性的5-HT1A受体和多巴胺受体的激动剂，其IC50值

分别为6.5nM(rat5-HT1A)、0.1nM(human5-HT1A)、15.1nM(ratD2)、17nM(humanD2)、6.8nM

(humanD3)和2.4nM(humanD4.2)。

IC50Target5-HT1AReceptorHumanD3Receptor5-HT2AReceptor5-HT2BReceptor

0.1nM(IC50)6.8nM(IC50)587nM(IC50)108nM(IC50)

5-HT5AReceptorHuman5-HT6Human5-HT7

313nM(IC50)ReceptorReceptor

3300nM(IC50)10nM(IC50)

客户使⽤本产品发表的科研⽂献

•CellDeathDis.2024Jun12;15(6):411.

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REFERENCES

[1].GDBartoszyk,etal.Sarizotan,aSerotonin5-HT1AReceptorAgonistandDopamineReceptorLigand.JNeuralTransm(Vie