Bayer-18-生命科学试剂-MCE.pdf

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Bayer-18

Cat.No.:HY-18315

CASNo.:1251752-12-1

分⼦式:C₁₉H₂₇FN₆O₂

分⼦量:390.46

作⽤靶点:JAK;Apoptosis

作⽤通路:Epigenetics;JAK/STATSignaling;ProteinTyrosine

Kinase/RTK;StemCell/Wnt;Apoptosis

储存⽅式:Powder-20°C3years

4°C2years

Insolvent-80°C6months

-20°C1month

BIOLOGICALACTIVITY

⽣物活性Bayer-18是TYK2的抑制剂。Bayer-18抑制间变性⼤细胞淋巴瘤细胞K299，SR786，Mac1和Mac2a活⼒，

IC50为2-3µM，并在K299和SR786细胞中诱导凋亡(apoptosis)。

IC50TargetTyk2

REFERENCES

[1].PrutschN,etal.,DependencyontheTYK2/STAT1/MCL1axisinanaplasticlargecelllymphoma.Leukemia.2019Mar;33(3):696-709.

doi:10.1038/s41375-018-0239-1.Epub2018Aug21.Erratumin:Leukemia.2020Nov;34(11):3105.

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