AMG131-benzenesulfonate-INT131-benzenesulfonate-生命科学试剂-MCE.pdf

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AMG131benzenesulfonate

Cat.No.:HY-117103A

CASNo.:849738-78-9

Synonyms:INT131benzenesulfonate

分⼦式:C₂₇H₁₈Cl₄N₂O₆S₂

分⼦量:672.38

作⽤靶点:PPAR

作⽤通路:CellCycle/DNADamage;MetabolicEnzyme/Protease;Vitamin

DRelated/NuclearReceptor

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性AMG131(INT131)(benzenesulfonate)是⼀种有效的⾮噻唑烷酮(TZD)选择性过氧化物酶体增殖物激活受体

γ调节剂(SPPARM)。AMG131(benzenesulfonate)与TZD在同⼀结合⼝袋内与PPARγ结合，但在⼝袋中占

据⼀个独特的空间，并在与TZD不同的点接触受体。AMG131(benzenesulfonate)有望⽤于2型糖尿病的研

究[1]。

REFERENCES

[1].HigginsLS,etal.TheDevelopmentofINT131asaSelectivePPARgammaModulator:ApproachtoaSaferInsulinSensitizer.PPAR

Res.2008;2008:936906.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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