卵巢癌的诊断和治疗(医大讲课).ppt

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卵巢癌的诊断和治疗(医大讲课).ppt

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DiagnosisandTreatmentofOvarianCancerShenKengDepartmentofOB/GYNPekingUnionMedicalCollegeHospital

EpidemiologyandGeneticFactorsOvariancanceristhesecondmostcommongynecologicalmalignancy,butthecommonestmalignancyofthefemalegenitaltracttoresultindeathIncidence:Ingeneralpopulationlifetimeriskforovariancancerinawomenisroughly1/70or1.4%.

EpidemiologyandGeneticFactorsThemostcommontumortypeisepithelial(85%).TheincidenceinAsia,AfricaandLatinAmericaislowerthaninWesterncountries.

卵巢癌的危险因素添加标题年龄01添加标题危险因素02添加标题与子宫内膜、结肠、乳腺癌的关系03添加标题家庭史04添加标题生产史和激素水平05

Morethan40yrs.01Caucasianrace(white)02Latemenopause.03Infertility04PositivefamilyhistoryofCAovary05BRCAgene06EpidemiologyandGeneticFactorsHighriskfactors:

EpidemiologyandGeneticFactorsFamilyhistoryisthestrongestriskfactorforovariancancerWomenwithoneaffectedfirstclassrelative:riskrateforovariancanceris5%Womenwithtwoaffectedfirstclassrelative:riskrateforovariancanceris7%AmemberofHOCS:riskrateforovariancanceris20%--50%BRCA1BRCA2geneassociatedwithHOCS

EpidemiologyandGeneticFactorsPreventionprotectivefactorsforovariancancerappeartobeconditionsassociatedwithfewerlifetimeovulations1.Useoforalcontraceptivepills2.Shorterdurationofreproductiveyears3.Conditionsofchronicanovulation4.Historyofbreastfeeding5.Multiparity

HistopathologyEpithelialovariancancer,usuallyclassedsimplyasadenocarcinoma,includeanumberofspecifichistologicaltypes:SerousadenocarcinomaMuconousadenocarcinomaEndometrioidadenocarcinomaMalignantBrennertumor(transitionalcell)Clearcelladenocarcinoma

HistopathologyMalignantGermCellTumoroftheOvaryincludeanumberofspecifichistologicaltypes:DysgerminomaYolk-SacTumor(endodermalsinustumor)TeratomasChoriocarcinomaMixedgermcell