TCP1通过P53调控Wnt7b-β-catenin信号通路影响肝癌细胞的增殖和迁移.pdfVIP

TCP1通过P53调控Wnt7b-β-

catenin信号通路影响肝癌细胞的增

殖和迁移

摘要：

本研究旨在探究TCP1通过P53调控Wnt7b/β-catenin信号通

路对肝癌细胞增殖和迁移的影响。我们通过Western

blotting发现，在正常肝组织和肝癌组织中，TCP1在肝癌组

织中呈现出显著高表达。进一步的实验表明，TCP1可以促进

肝癌细胞的增殖和迁移，而过表达P53可以抑制TCP1的增殖

和迁移作用。此外，我们还发现Wnt7b/β-catenin信号通路

是TCP1促进肝癌细胞增殖和迁移的基础。通过抑制

Wnt7b/β-catenin信号通路，我们可以抑制TCP1对肝癌细胞

增殖和迁移的促进作用。综上所述，TCP1通过P53调控

Wnt7b/β-catenin信号通路参与调控肝癌细胞的增殖和迁移，

为肝癌的治疗提供了新的靶点。

关键词：TCP1；P53；Wnt7b/β-catenin；肝癌细胞；增殖和

迁移

Abstract:

Thepresentstudyaimedtoinvestigatetheinfluence

ofTCP1mediatedbyP53onWnt7b/β-cateninsignal

transductionpathwaysfortheproliferationand

migrationoflivercancercells.Wefoundthatthe

TCP1wasexpressedremarkablyhigherinlivercancer

tissuesthaninnormallivertissuesthroughWestern

blotting.FurtherexperimentsshowedthatTCP1could

promotetheproliferationandmigrationofliver

cancercells,whileoverexpressedP53caninhibit

TCP1sproliferationandmigrationeffects.In

addition,wefoundthatWnt7b/β-cateninsignal

transductionpathwaywasthebasisforTCP1topromote

theproliferationandmigrationoflivercancercells.

ByinhibitingtheWnt7b/β-cateninsignaltransduction

pathway,wecansuppressTCP1spromotionofliver

cancercellproliferationandmigration.Insummary,

TCP1mediatedbyP53participatesintheregulationof

theproliferationandmigrationoflivercancercells

throughWnt7b/β-cateninsignaltransductionpathways,

whichprovidesanewtargetforthetreatmentofliver

cancer.

Keywords:TCP1;P53;Wnt7b/β-catenin;livercancer

cells;proliferationandmigration

Livercancerisamalignanttumorthathashigh

morbidityandmortalityratesworldwide.The

progressionandmetastasisoflivercancerare

associatedwithvarioussignalingpathwaysthat

regulatecellproliferationandmigration.Onesuch

pathwayistheWnt/β-cateninsignalingpathway,which

playsacrucialroleinthe