BMS-202-hydrochloride-生命科学试剂-MCE.pdf

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BMS-202hydrochloride

Cat.No.:HY-19745B

CASNo.:2089334-95-0

分⼦式:C₂₅H₃₀ClN₃O₃

分⼦量:455.98

作⽤靶点:PD-1/PD-L1;Apoptosis

作⽤通路:Immunology/Inflammation;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性BMS-202hydrochloride是⼀种有效的⾮肽类PD-1/PD-L复合物抑制剂，其IC50为18nM，KD为8μM。

BMS-202hydrochloride与PD-L1直接结合并阻断⼈类PD-1/PD-L的相互作⽤。BMS-202hydrochloride具有

抗肿瘤活性。

客户使⽤本产品发表的科研⽂献

•NanoToday.2022,47:101689.

•ACSNano.2024Feb20;18(7):5632-5646.

•NatCommun.2021Dec9;12(1):7155.

•ActaPharmSinB.22October2021.

•BiomaterRes.2023Nov24;27(1):120.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].ZakKM,etal.Structuralbasisforsmallmoleculetargetingoftheprogrammeddeathligand1(PD-L1).Oncotarget.2016May

24;7(21):30323-35.

[2].AshizawaT,etal.AntitumoractivityofthePD-1/PD-L1bindinginhibitorBMS-202inthehumanizedMHC-doubleknockoutNOGmouse.

BiomedRes.2019;40