Cilofexor-tromethamine-GS-9674-tromethamine-生命科学试剂-MCE.pdf

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Cilofexortromethamine

Cat.No.:HY-109083A

CASNo.:2253764-93-9

Synonyms:GS-9674tromethamine

分⼦式:C₃₂H₃₃Cl₃N₄O₈

分⼦量:707.99

作⽤靶点:Autophagy;FXR

作⽤通路:Autophagy;MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Cilofexortromethamine(GS-9674tromethamine)是⼀种⾮类固醇法尼烯氧化物受体激动剂，具有改善胆汁

淤积和肝损伤标志物的活性。Cilofexortromethamine在⽆肝硬化的患者中显⽰了良好的耐受性，并导致肝⽣

化指标和胆汁淤积标志物的显著改善。Cilofexortromethamine为处理原发性硬化性胆管炎提供了潜在的抑制

选择。

客户使⽤本产品发表的科研⽂献

•Science.2023Jun9;380(6649):eabo2296.

•NatCommun.2024May13;15(1):4034.

•JHEPRep.2023Sep25,100917.

•BiomedPharmacother.2024Feb29:173:116331.

•ArchToxicol.2022Mar10.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].TraunerM,etal.TheNonsteroidalFarnesoidXReceptorAgonistCilofexor(GS-9674)ImprovesMarkersofCholestasisandLiverInjury

inPatientsWithPrimarySclerosingCholangitis.Hepatology.2019Sep;70(3):788-801.

[2].PatelK,etal.Cilofexor,aNonsteroidalFXRAgonist,inNon-CirrhoticPatientswithNonalcoholicSteatohepatitis:APhase2

RandomizedControlledTrial.Hepatology.2020Mar1.

1/2MasterofBioactiveMolecules—