Miricorilant-CORT-118335-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Miricorilant

Cat.No.:HY-117965

CASNo.:1400902-13-7

Synonyms:CORT118335

分⼦式:C₂₄H₂₃F₃N₂O₂

分⼦量:428.45

作⽤靶点:GlucocorticoidReceptor;MineralocorticoidReceptor

作⽤通路:Immunology/Inflammation;VitaminDRelated/Nuclear

Receptor;MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Miricorilant(CORT118335)是⼀种双重选择性糖⽪质激素(GR)调节剂/盐⽪质激素(MR)拮抗剂。Miricorilant

可⽤于研究下丘脑-垂体-肾上腺(HPA)轴相关的疾病[1]。

IC50TargetGlucocorticoid/Mineralocorticoid[1]

体内研究CORT118335(3-30mg/kg)potentlysuppressesendocrineresponsestotwodifferentstressors(restraint

andFST)inmalerats[1].

AnimalModel:MaleSprague-Dawleyrats(≈250g)[1]

Dosage:3mg/kg,10mg/kg,30mg/kg

Administration:Subcutaneously(s.c.);fivedays.

Result:30mg/kghadlowercorticosteroneresponsesrelativeto10mg/kgat15and30mintime

points.

REFERENCES

[1].ElizabethTNguyen,etal.AMixedGlucocorticoid/MineralocorticoidReceptorModulatorDampensEndocrineandHippocampalStres