Cyclorasin-9A5-TFA-生命科学试剂-MCE.pdf

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Cyclorasin9A5TFA

Cat.No.:HY-P10051A

分⼦式:C₇₅H₁₀₈FN₂₅O₁₃.xC₂HF₃O₂

Sequence:Cyclo({d-Ala}-Arg-Arg-Arg-{d-Nal}-Arg-{4F-Phe}-{d-Nle}-Gln-Tr

p-Thr)

SequenceShortening:Cyclo({d-Ala}-RRR-{d-Nal}-R-{4F-Phe}-{d-Nle}-QWT)

作⽤靶点:Ras;Raf

作⽤通路:GPCR/GProtein;MAPK/ERKPathway

储存⽅式:Sealedstorage,awayfrommoisture

Powder-80°C2years

-20°C1year

Insolvent-80°C6months

-20°C1month

溶解性数据

体外实验H2O:≥100mg/mL

*≥meanssoluble,butsaturationunknown.

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造

成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrom

moisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。

BIOLOGICALACTIVITY

⽣物活性Cyclorasin9A5TFA是⼀种具有11个残基的细胞渗透环肽，抑制Ras-Raf蛋⽩的相互作⽤，其IC50值为120

nM。

IC50TargetIC50:120nM(Ras-Rafproteininteraction)[1].

REFERENCES

[1].KohTakeuchi,