15-R-Lipoxin-A4-15-epi-LXA4-生命科学试剂-MCE.pdf

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15(R)-LipoxinA4

Cat.No.:HY-113509B

CASNo.:171030-11-8

Synonyms:15-epi-LXA4

分⼦式:C₂₀H₃₂O₅

分⼦量:352.47

作⽤靶点:STAT

作⽤通路:JAK/STATSignaling;StemCell/Wnt

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性15(R)-LipoxinA4(15-epi-LXA4)是⼀种STAT-6激活剂，是脂质衍⽣的脂氧素类型的解决介质(SPMs)，具有促

进炎症解决和免疫细胞功能调节的作⽤。15(R)-LipoxinA4可改善微胶质细胞的吞噬功能，具有抗炎活性。15(

R)-LipoxinA4阿尔茨海默病(AD)的⼩⿏模型中可改善AD样病理。15(R)-LipoxinA4有望⽤于炎症及神经疾病

研究[1]。

IC50TargetSTAT6

REFERENCES

[1].LeeJY,etal.NeuronalSphK1acetylatesCOX2andcontributestopathogenesisinamodelofAlzheimersDisease.NatCommun.2018

Apr16;9(1):1479.

[2].DakinSG,etal.15-Epi-LXA4andMaR1counterinflammationinstromalcellsfrompatientswithAchillestendinopathyandrupture[J].

TheFASEBJournal,2019,33(7):8043.

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