BMP-4-生命科学试剂-MCE.pdf

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BMP-4

Cat.No.:HY-P10710

CASNo.:1629625-47-3

分⼦式:C₅₂H₉₃N₂₅O₁₃S

分⼦量:1308.52

Sequence:Arg-Lys-Lys-Asn-Pro-Asn-Cys-Arg-Arg-His

SequenceShortening:RKKNPNCRRH

作⽤靶点:IFNAR;InterleukinRelated;COX

作⽤通路:Immunology/Inflammation

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性BMP-4是⼀种穿透肝素结合肽，具有抗炎和抗软⾻形成功能。在⼩⿏软⾻细胞和巨噬细胞中，BMP-4通过调

控iNOS-IFN-IL6信号通路，以剂量依赖的⽅式抑制iNOS、COX2、IFN和IL6等炎症蛋⽩的表达，来有效抑制

炎症并缓解多种关节炎症状[1]。

IC50TargetIL-6COX-2

REFERENCES

[1].PathadeV,etal.Emerginginsightsofpeptide-basednanotherapeuticsforeffectivemanagementofrheumatoidarthritis.LifeSci.2023

Jan1;312:121257.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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